David N Herndon Selected Research

Human Growth Hormone (Saizen)

3/2011	Burns: where are we standing with propranolol, oxandrolone, recombinant human growth hormone, and the new incretin analogs?
10/2009	Randomized controlled trial to determine the efficacy of long-term growth hormone treatment in severely burned children.
3/2008	Combination of recombinant human growth hormone and propranolol decreases hypermetabolism and inflammation in severely burned children.
10/2005	Post burn muscle wasting and the effects of treatments.
9/2005	Metabolic and hormonal changes of severely burned children receiving long-term oxandrolone treatment.
10/2004	Effect of growth factors as therapeutic drugs on hepatic metabolism during the systemic inflammatory response syndrome.
7/2004	Growth hormone effects on hypertrophic scar formation: a randomized controlled trial of 62 burned children.
4/2003	Growth hormone down-regulation of Interleukin-1beta and Interleukin-6 induced acute phase protein gene expression is associated with increased gene expression of suppressor of cytokine signal-3.
2/2002	Vitamin D depletion following burn injury in children: a possible factor in post-burn osteopenia.

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David N Herndon Research Topics

Disease

323	Burns 01/2021 - 01/2002
93	Wounds and Injuries (Trauma) 01/2021 - 05/2002
61	Sepsis (Septicemia) 11/2019 - 01/2002
48	Infections 01/2020 - 07/2002
30	Acute Lung Injury 12/2012 - 09/2002
27	Inflammation (Inflammations) 01/2021 - 02/2003
24	Smoke Inhalation Injury 11/2017 - 02/2005
22	Insulin Resistance 01/2018 - 03/2003
20	Critical Illness (Critically Ill) 12/2018 - 11/2003
16	Cicatrix (Scar) 01/2020 - 02/2002
16	Hyperglycemia 01/2018 - 09/2002
16	Acute-Phase Reaction 03/2015 - 01/2002
13	Airway Obstruction (Choking) 01/2018 - 02/2003
11	Pneumonia (Pneumonitis) 01/2020 - 09/2002
11	Body Weight (Weight, Body) 09/2013 - 11/2002
10	Lung Injury 06/2011 - 03/2003
9	Wound Infection (Wound Infections) 01/2012 - 06/2003
8	Septic Shock (Toxic Shock Syndrome) 11/2019 - 09/2005
8	Edema (Dropsy) 05/2015 - 09/2002
7	Pulmonary Edema 12/2012 - 02/2003
6	Contracture 01/2021 - 09/2003
6	Hyperinsulinism (Hyperinsulinemia) 01/2019 - 09/2002
6	Hypertrophic Cicatrix (Hypertrophic Scar) 01/2018 - 04/2004
6	Shock 11/2017 - 05/2006
5	Pain (Aches) 12/2018 - 05/2006
5	Multiple Organ Failure (MODS) 05/2014 - 07/2009

Drug/Important Bio-Agent (IBA)

62	Proteins (Proteins, Gene)FDA Link 01/2019 - 01/2002
45	SmokeIBA 02/2016 - 09/2002
42	CytokinesIBA 01/2020 - 05/2002
38	Insulin (Novolin)FDA Link 06/2015 - 09/2002
28	Propranolol (Inderal)FDA LinkGeneric 01/2020 - 08/2002
26	Glucose (Dextrose)FDA LinkGeneric 09/2019 - 11/2002
22	Muscle Proteins (Muscle Protein)IBA 01/2019 - 01/2002
19	salicylhydroxamic acid (SHAM)IBA 01/2018 - 12/2002
18	Oxandrolone (Anavar)FDA LinkGeneric 01/2020 - 06/2003
14	Interleukin-6 (Interleukin 6)IBA 01/2020 - 04/2004
14	Acute-Phase Proteins (Acute-Phase Protein)IBA 03/2015 - 04/2003
14	Insulin-Like Growth Factor I (IGF-1)IBA 10/2011 - 05/2002
13	Interleukin-12 (IL 12)IBA 10/2012 - 10/2002
12	Hormones (Hormone)IBA 01/2019 - 05/2005
12	Interleukin-10 (Interleukin 10)IBA 12/2014 - 07/2002
11	CatecholaminesIBA 01/2020 - 09/2007
11	Phenylalanine (L-Phenylalanine)FDA Link 01/2019 - 09/2002
11	IsotopesIBA 01/2019 - 04/2007
11	CollagenIBA 03/2016 - 04/2004
10	Biomarkers (Surrogate Marker)IBA 09/2019 - 09/2010
10	Growth Hormone (Somatotropin)IBA 06/2015 - 10/2002
10	Nitric Oxide (Nitrogen Monoxide)FDA Link 11/2011 - 09/2004
9	Pharmaceutical PreparationsIBA 01/2019 - 10/2002
9	Human Growth Hormone (Saizen)FDA LinkGeneric 03/2011 - 02/2002
8	LipidsIBA 01/2019 - 04/2007
8	CarbohydratesIBA 01/2019 - 08/2002
8	InterleukinsIBA 09/2012 - 07/2002
8	Hydrocortisone (Cortisol)FDA LinkGeneric 01/2012 - 06/2004
7	Messenger RNA (mRNA)IBA 01/2019 - 06/2004
7	Adenosine Triphosphate (ATP)IBA 01/2018 - 08/2008
7	Oxygen (Dioxygen)IBA 11/2016 - 01/2003
7	Amino Acids FDA Link 09/2013 - 09/2002
6	CalciumIBA 01/2021 - 01/2004
6	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 01/2020 - 09/2002
6	EnzymesIBA 01/2020 - 10/2003
6	Peroxynitrous Acid (Peroxynitrite)IBA 11/2019 - 09/2004
6	Peroxidase (Myeloperoxidase)IBA 01/2019 - 03/2010
6	Nonesterified Fatty Acids (NEFA)IBA 01/2019 - 08/2002
6	Metformin (Glucophage)FDA LinkGeneric 01/2018 - 03/2003
6	Anti-Bacterial Agents (Antibiotics)IBA 12/2017 - 01/2002
6	Interleukin-8 (Interleukin 8)IBA 03/2015 - 01/2007
6	LigandsIBA 09/2012 - 06/2004
5	Nitric Oxide Synthase Type II (Inducible Nitric Oxide Synthase)IBA 01/2020 - 05/2006
5	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2020 - 01/2009
5	Reactive Nitrogen SpeciesIBA 11/2019 - 02/2011
5	Malondialdehyde (Propanedial)IBA 01/2018 - 02/2011
5	Adrenergic Receptors (Adrenergic Receptor)IBA 01/2018 - 09/2007
5	Epinephrine (Adrenaline)FDA LinkGeneric 11/2017 - 04/2008
5	Blood Glucose (Blood Sugar)IBA 05/2014 - 06/2010
5	Triglycerides (Triacylglycerol)IBA 01/2013 - 08/2002
5	3-nitrotyrosineIBA 11/2012 - 07/2007
5	DNA (Deoxyribonucleic Acid)IBA 09/2012 - 06/2008
5	CC ChemokinesIBA 09/2012 - 06/2004
5	Interleukin-4 (Interleukin 4)IBA 09/2008 - 07/2002
5	Insulin-Like PeptidesIBA 05/2007 - 01/2002
4	brassIBA 01/2021 - 12/2015
4	Testosterone (Sustanon)FDA Link 01/2020 - 10/2005
4	Norepinephrine (Noradrenaline)FDA LinkGeneric 11/2019 - 06/2004
4	NitrogenIBA 01/2019 - 07/2007
4	CreatinineIBA 01/2019 - 03/2003
4	Superoxides (Superoxide)IBA 01/2018 - 02/2005
4	Caspase 3 (Caspase-3)IBA 02/2016 - 10/2003

Therapy/Procedure

41	Therapeutics 01/2020 - 09/2002
26	Length of Stay 01/2021 - 01/2002
26	Resuscitation 01/2020 - 03/2003
12	Critical Care (Surgical Intensive Care) 01/2017 - 02/2003
9	Debridement 10/2018 - 01/2002
9	Autologous Transplantation 09/2012 - 02/2003
8	Mechanical Ventilators (Ventilator) 11/2017 - 01/2002
8	Enteral Nutrition (Feeding, Tube) 07/2017 - 01/2002
8	Anesthesia 12/2012 - 05/2006
6	Nutritional Support (Artificial Feeding) 01/2011 - 04/2003
4	Drug Therapy (Chemotherapy) 01/2018 - 03/2003
4	Aftercare (After-Treatment) 12/2017 - 08/2004